The Spatiotemporal Organization of ErbB Receptors: Insights from Microscopy
- 1Department of Pathology and the Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico 87131
- 2Department of Physics and Astronomy, University of New Mexico, Albuquerque, New Mexico 87131
- Correspondence: dlidke{at}salud.unm.edu
Abstract
Signal transduction is regulated by protein–protein interactions. In the case of the ErbB family of receptor tyrosine kinases (RTKs), the precise nature of these interactions remains a topic of debate. In this review, we describe state-of-the-art imaging techniques that are providing new details into receptor dynamics, clustering, and interactions. We present the general principles of these techniques, their limitations, and the unique observations they provide about ErbB spatiotemporal organization.
- Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved
